Allergy Notes

As of January 2023, AIRSUPRA (albuterol/budesonide), has been approved in the US for the as-needed treatment or prevention of bronchoconstriction and to reduce the risk of exacerbations in people...

http://allergynotes.blogspot.com/2023/01/sabaics-prn-combo-for-asthma-airsupra.html

Allergic rhinitis was associated with a broad range of sleep problems and to a lesser extent in children with asthma and least in children with eczema. ALLERGIC RHINITIS was associated with: -...

http://allergynotes.blogspot.com/2022/09/allergic-diseases-and-sleep-problems-in.html

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a severe cutaneous adverse reaction to drugs. The disease carries considerable morbidity and mortality. Immunomodulators for SJS...

http://allergynotes.blogspot.com/2022/09/add-on-etanercept-as-treatment-for.html

The article argues against the hygiene hypothesis for causation of allergic diseases: https://www.annallergy.org/article/S1081-1206(22)00585-3/fulltext The authors make the case that the basic ...

http://allergynotes.blogspot.com/2022/09/against-hygiene-hypothesis-as-cause-of.html

Chronic rhinosinusitis with nasal polyps is frequently managed with endoscopic sinus surgery (ESS). Prior studies describe individual clinical variables and eosinophil density measures as prognos...

http://allergynotes.blogspot.com/2022/09/prognostic-factors-for-polyp-recurrence.html

Atopic dermatitis (AD) is the MOST COMMON CHRONIC INFLAMMATORY SKIN DISEASE. AD can be very challenging to manage. AD is characterized by: - dense cutaneous dendritic cell and T-cell infiltrat...

http://allergynotes.blogspot.com/2022/09/blood-endotypic-signatures-in-atopic.html

EOSINOPHILIC GASTROINTESTINAL (GI) DISEASES (EGIDS) are characterized by tissue eosinophilia and symptoms of esophageal or GI dysfunction. Eosinophilic esophagitis (EoE) diagnostic criteria are w...

http://allergynotes.blogspot.com/2022/09/eosinophilic-gastrointestinal-diseases.html

Chronic rhinosinusitis (CRS) has a major clinical impact and affects 10% of the US population. CRS presents with 2 MAJOR PHENOTYPES: - CRS with NASAL POLYPS (CRSwNP) - CRS without nasal polyps...

http://allergynotes.blogspot.com/2022/09/chronic-rhinosinusitis-future.html

T2 inflammation is characterized by elevations in: - absolute peripheral or sputum eosinophil counts - levels of IgE (total and allergen-specific) - fractional exhaled nitric oxide (FeNO) The ...

http://allergynotes.blogspot.com/2022/09/t2-inflammation-biomarkers-and-cytokines.html

Aquagenic urticaria (AquaU) is a rare variant of chronic inducible urticaria. In AquaU wheals occur after skin contact with water. AquaU can be CLASSIFIED AS: - FAMILIAL AquaU (FAquaU, 18%) -...

http://allergynotes.blogspot.com/2022/09/aquagenic-urticaria.html

Mastocytosis is a myeloid neoplasm. It is defined by expansion and focal accumulation of clonal mast cells (MCs) in one or more organs. MASTOCYTOSIS HAS A COMPLEX PATHOLOGY and may be complicat...

http://allergynotes.blogspot.com/2022/09/personalized-management-strategies-in.html

Nontryptase Urinary and Hematologic Biomarkers of Mast Cell Activation include: - URINARY METABOLITES OF HISTAMINE - urine and serum or plasma PROSTAGLANDIN D2 - urine or plasma LEUKOTRIENE E4 ...

http://allergynotes.blogspot.com/2022/09/nontryptase-urinary-and-hematologic.html

Tryptase levels in serum can be used for diagnosis and management of: - CLONAL mast cell disorders such as mastocytosis - severe mast cell–dependent SYSTEMIC REACTIONS such as anaphylaxis HER...

http://allergynotes.blogspot.com/2022/08/tryptase-genotyping-for-diagnosis-of.html

Mastocytosis is a group of rare and heterogeneous diseases. They are characterized by an increased accumulation of abnormal mast cells in various organs/tissues. The pathogenesis of mastocytosi...

http://allergynotes.blogspot.com/2022/08/genetic-testing-in-diagnosis-and.html

MAST CELL ACTIVATION (MCA) is common and occurs in a NUMBER OF CONDITIONS, including: - IgE-dependent and independent allergic reactions - atopic disorders - autoimmune processes - mastocytosis ...

http://allergynotes.blogspot.com/2022/08/mast-cell-activation-disorders-mcads.html

The FDA has a specific warning about Evusheld - it should be include in the informed consent, esp. since the prophylaxis use is off-label: WARNINGS/PRECAUTIONS CONCERNS RELATED TO ADVERSE EF...

http://allergynotes.blogspot.com/2022/03/cardiovascular-risks-with-tixagevimab.html

  Adverse Food Reactions (click to enlarge the image ). UP TO 20% OF PEOPLE DEVELOP GASTROINTESTINAL (GI) SYMPTOMS FOLLOWING A MEAL. Millions of people have chronic symptoms labeled as funct...

http://allergynotes.blogspot.com/2021/06/the-idea-of-local-allergic-rhinitis-now.html

Dr. Ellis @DrAnneEllis: Next up we have Dr. Syed Ashad - Risk factors for developing allergic disease - Lessons from the Isle of Wight. The Isle of Wight cohort has 1536 parents and 495 childr...

http://allergynotes.blogspot.com/2020/07/modifiable-risk-factors-for-development.html

Atoosa Kourosh @AllergyHealth: 30% of patients with true cannabis allergy will test negative to Can S 3 so it’s good to send component testing from http://pirllab.com and @thermofisher Nico...

http://allergynotes.blogspot.com/2020/07/cannabis-allergy-acaai19-twitter-summary.html

Dr Alexei Gonzalez @alexeigonzmd: ESID data: between 5-66% of patients with CVID will develop Lund disease; 1/4 will have ILD. GLILD has three pathologic patterns: granulomas, lymphocytic inter...

http://allergynotes.blogspot.com/2020/07/primary-immunodeficiency-disease-pidd.html

Dr. Ellis @DrAnneEllis: Gearing up to moderate/facilitate my new favourite workshop "Hands On - The use of Case Simulation for the Education of Allergic Emergencies - Spotlight on Anaphylaxis". ...

http://allergynotes.blogspot.com/2020/07/case-simulation-for-education-on.html

Dr. Ellis @DrAnneEllis Dr. Justin Greiwe - Best practices for oral food challenges on infants - which patients and when? FOOD ALLERGY IS A FAMILY DISEASE, NOT AN INDIVIDUAL PROBLEM. Huge soci...

http://allergynotes.blogspot.com/2020/07/food-challenges-in-infants-acaai19.html

Dr. Ellis @DrAnneEllis Professor Stephen Holgate - Asthma - Inflammation is the Symptom not the Cause. Epithelial injury and airway remodeling are a common feature of even mild asthma. Beyo...

http://allergynotes.blogspot.com/2020/07/asthma-acaai19-twitter-summary.html

Dr. Ellis @DrAnneEllis Pork kidney allergy is driven by alpha-gal allergy. Co-authors such as exercise needed to elicit reactions. Jason K Lee @lee_jasonk 19% OF FORREST WORKERS AND HUNTERS HAV...

http://allergynotes.blogspot.com/2020/07/alpha-gal-food-allergy-acaai19-twitter.html

Kevin Parks MD @kparksmd Presidential Plenary at #ACAAI19 Matt Rank MD on EoE: how long do we continue topical glucocorticoids in responders? Very low quality of evidence, but the committee recom...

http://allergynotes.blogspot.com/2020/07/eosinophilic-esophagitis-acaai19.html