For most patients, it's unknown exactly what causes amyotrophic lateral sclerosis (ALS), a disease characterized by degeneration of motor neurons that impairs muscle control and eventually leads ...
https://medicalxpress.com/news/2024-05-epigenomic-analysis-factors-amyotrophic-lateral.html
The length of telomeres in white blood cells, known as leukocytes, varies significantly among sub-Saharan African populations, researchers report in The American Journal of Human Genetics. Moreov...
https://medicalxpress.com/news/2024-05-malaria-shorten-leukocyte-telomeres-saharan.html
Genetics can be associated with one's behavior and health—from the willingness to take risks, and how long one stays in school, to chances of developing Alzheimer's disease and breast cancer. A...
https://medicalxpress.com/news/2024-05-companies-buy-consumer-genetic-modest.html
In an article published in Nature, researchers from Karolinska Institutet present an atlas of the early development of the brain. The atlas can be used, among other things, to find out what went ...
https://medicalxpress.com/news/2024-05-early-genetic-brain.html
Researchers analyzing the DNA of people with kidney cancer worldwide have found evidence of an unknown trigger that could explain the longstanding mystery of why some countries have a higher inci...
https://medicalxpress.com/news/2024-05-unknown-factor-linked-high-kidney.html
Rett syndrome is a rare neurodevelopmental disorder for which there is currently no cure or good therapy. It causes severe physical and cognitive symptoms, including many that overlap with autism...
A type of cell responsible for repairing damaged liver tissue has been uncovered for the first time by scientists.
Nonsense-mediated RNA decay, or NMD, is an evolutionarily conserved molecular mechanism in which potentially defective messenger RNAs, or mRNAs (genetic material that instructs the body on how to...
https://medicalxpress.com/news/2024-05-discusses-mechanism-birth-defect-affecting.html
In 2016, The Jackson Laboratory (JAX) launched the Maine Cancer Genomics Initiative (MCGI) to bring the latest progress in cancer care to rural Maine patients. Now, after successfully expanding a...
https://medicalxpress.com/news/2024-05-cancer-patients-gain-important-benefits.html
St. Jude Children's Research Hospital scientists have identified specific DNA variants in the non-coding regions of the genome contributing to chemotherapy resistance in acute lymphoblastic leuke...
https://medicalxpress.com/news/2024-05-unraveling-roles-coding-dna-childhood.html
Researchers from Children's Hospital of Philadelphia (CHOP) have identified a causal genetic variant strongly associated with childhood obesity. The study provides new insight into the importance...
https://medicalxpress.com/news/2024-05-causal-genetic-variant-linked-common.html
Proteins are the workhorses of life. Organisms use them as building blocks, receptors, processors, couriers and catalysts. A protein's structure is critical to its function. Malformed proteins no...
https://medicalxpress.com/news/2024-04-reveal-approach-degenerative-diseases.html
While previous studies have investigated the function of the protein Bcl6 in dendritic cells—in some cases with varying results—a new study published in Nature Communications has sought to ha...
https://medicalxpress.com/news/2024-04-bcl6-protein-important-transcription-factor.html
University at Buffalo researchers have found that the active form of a gene promotes a broad range of protective traits. The gene is found in 75% of the population and is known to protect against...
https://medicalxpress.com/news/2024-04-people-uniquely-human-gene-immune.html
New research from the University of Aberdeen could lead to the development of medication for disease that affects 1 in 4 people worldwide but is currently untreatable.
https://medicalxpress.com/news/2024-04-gene-linked-fatty-liver-disease.html
Researchers led by Queen Mary University of London have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. ...
https://medicalxpress.com/news/2024-04-genetic-linked-blood-pressure-million.html
National Institutes of Health researchers and collaborators have discovered over 100 new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressur...
https://medicalxpress.com/news/2024-04-genetic-markers-differences-people-blood.html
A study in mice suggests how chromosome inactivation may protect girls from a type of autism disorder inherited from their father's X chromosome.
https://medicalxpress.com/news/2024-04-chromosome-inactivation-autism-mice.html
A healthy lifestyle may offset the effects of life-shortening genes by more than 60%, suggests an analysis of the findings from several large long-term studies, published online in the journal BM...
https://medicalxpress.com/news/2024-04-healthy-lifestyle-offset-effects-life.html
Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit. In our cells, molecules called...
https://medicalxpress.com/news/2024-04-method-rapidly-reveals-protein-modifications.html
The core experiences of depression—changes in energy, activity, thinking and mood—have been described for more than 10,000 years. The word "depression" has been used for about 350 years.
https://medicalxpress.com/news/2024-04-genetic-clues-depression-people.html
Researchers have discovered the mechanism which allows adult brain stem cells to express genes that maintain their identity and those for neuronal differentiation without conflicts in cellular ac...
https://medicalxpress.com/news/2024-04-uncovers-mechanism-conflicts-brain-stem.html
Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its effects on patients...
https://medicalxpress.com/news/2024-04-years-uncover-genetic-rare-neurological.html
A genetic change or variant in a gene called SCN2A is a known cause of infantile seizures, autism spectrum disorder, and intellectual disability, as well as a wide range of other moderate-to-prof...
https://medicalxpress.com/news/2024-04-gene-linked-epilepsy-autism-decoded.html
A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to the rare genetic condition 22q11.2 deletion syndrome, or 22q. It found unique biomarke...
https://medicalxpress.com/news/2024-04-biomarkers-psychiatric-symptoms-patients-rare.html
There has been a breakthrough in the research on the disease amyotrophic lateral sclerosis (ALS). Scientists at Umeå University report that the disease progression in a patient with a particular...
https://medicalxpress.com/news/2024-04-scientists-gene-therapy-amyotrophic-lateral.html
In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genome that are associated with the risk of developing ki...
https://medicalxpress.com/news/2024-04-analysis-genomic-regions-kidney-cancer.html
A new study highlights possible cardiovascular health advantages in individuals with a rare condition known as growth hormone receptor deficiency (GHRD), also called Laron syndrome.
https://medicalxpress.com/news/2024-04-people-rare-longevity-mutation-cardiovascular.html
Shutting down a gene called PRMT5 stopped metastatic estrogen receptor-positive (ER+) breast cancer cells from growing after they acquired resistance to a standard therapy known as CDK4/6 inhibit...
https://medicalxpress.com/news/2024-04-blocking-gene-halt-growth-breast.html
A team of researchers at Johannes Gutenberg University Mainz (JGU) has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply ...
https://medicalxpress.com/news/2024-04-rna-modification-responsible-disruption-mitochondrial.html