In a Canadian discovery powered by philanthropy, a team of Western University researchers led by Dr. Michael Strong has uncovered a potential path toward a cure for amyotrophic lateral sclerosis ...
https://medicalxpress.com/news/2024-05-uncovers-protein-interactions-potential-path.html
Researchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson's disease (PD)...
https://medicalxpress.com/news/2024-05-genetic-link-inflammatory-bowel-disease.html
Approximately 31,000 people are living with amyotrophic lateral sclerosis (ALS) in the United States, with an average of 5,000 new cases every year, according to the Centers for Disease Control a...
https://medicalxpress.com/news/2024-05-vowel-intelligibility-people-als.html
Researchers from the UAB have identified a region in the early aggregates of the alpha-synuclein protein that can be targeted to prevent its conversion into the toxic amyloid fibrils that accumul...
https://medicalxpress.com/news/2024-05-therapeutic-neutralize-toxic-parkinson-protein.html
A preclinical study from Karolinska Institutet offers hope for treating severe neurodegenerative diseases with an existing drug. The study suggests that the leprosy drug clofazimine may be effect...
https://medicalxpress.com/news/2024-05-leprosy-drug-effective-huntington-disease.html
For most patients, it's unknown exactly what causes amyotrophic lateral sclerosis (ALS), a disease characterized by degeneration of motor neurons that impairs muscle control and eventually leads ...
https://medicalxpress.com/news/2024-05-epigenomic-analysis-factors-amyotrophic-lateral.html
Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease...
https://medicalxpress.com/news/2024-04-neurogenesis-approach-parkinson-disease.html
A team of Northwestern Medicine investigators has discovered novel DNA methylation patterns in the blood of patients with Parkinson's disease, according to findings published in Annals of Neurolo...
https://medicalxpress.com/news/2024-04-scientists-potential-biomarkers-environmental-exposures.html
A research team led by Professor Haruhisa Inoue (Department of Cell Growth and Differentiation) derived iPS cells (iPSC) from α-synucleinopathy patients with early-onset familial Parkinson's dis...
https://medicalxpress.com/news/2024-04-differentiating-cerebral-cortical-neurons-decipher.html
A new UCLA Health study has found that certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease.
https://medicalxpress.com/news/2024-04-genetic-variations-predispose-people-parkinson.html
Although there are still some aspects pending confirmation for its use in the clinical setting, and its resolution needs to be improved slightly, a study by the UPV/EHU and Biobizkaia has shown t...
https://medicalxpress.com/news/2024-04-retinal-thickness-cognitive-parkinson-patients.html
Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.
https://medicalxpress.com/news/2024-04-ai-drug-parkinson-ten.html
A new study from Van Andel Institute scientists offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinso...
https://medicalxpress.com/news/2024-04-scientists-cell-vulnerability-fingerprint-parkinson.html
Prasinezumab, a monoclonal antibody, is shown to reduce signs of motor deterioration in individuals with Parkinson's disease (PD) who have rapidly progressing disease, as reported in an explorato...
https://medicalxpress.com/news/2024-04-drug-rapid-parkinson-disease.html
Researchers at the University of Iowa in a new study have linked a region in the brain to how humans redirect thoughts and attention when distracted. The connection is important because it offers...
https://medicalxpress.com/news/2024-04-brain-region-involved-attention.html
Low-cost, wearable sensors could increase access to care for patients with Parkinson's disease. New machine-learning approaches and a baseline of data from healthy older adults improve the accura...
https://medicalxpress.com/news/2024-04-wearable-sensors-parkinson-machine-healthy.html
Over the last decade, researchers at the University of Michigan have continued to find that exposure to environmental toxins—from pesticides used in agriculture to volatile organic compounds in...
https://medicalxpress.com/news/2024-04-chemicals-home-garages-linked-amyotrophic.html
Parkinson's disease is a neurodegenerative movement disorder that progresses relentlessly. It gradually impairs a person's ability to function until they ultimately become immobile and often deve...
https://medicalxpress.com/news/2024-04-newly-genetic-variant-parkinson-disease.html
The nose or the gut? For the past two decades, the scientific community has debated the wellspring of the toxic proteins at the source of Parkinson's disease. In 2003, a German pathologist, Heiko...
https://medicalxpress.com/news/2024-04-hypothesis-emerges-parkinson-disease.html
Researchers have for the first time identified critical targets in the molecular signature of Parkinson's disease across different stages of the disease's progression.
https://medicalxpress.com/news/2024-04-advance-parkinson-disease.html
Parkinson's disease (PD) is a common neurodegenerative disease that affects millions worldwide. Now, a groundbreaking clinical study conducted by researchers at Ghent University Hospital, VIB, an...
https://medicalxpress.com/news/2024-04-stool-transplant-parkinson-disease.html
A drug used to treat diabetes slowed the progression of motor issues associated with Parkinson's disease, a study published in the New England Journal of Medicine said Wednesday.
https://medicalxpress.com/news/2024-04-diabetes-drug-parkinson-clinical.html
Researchers have used computational models to understand what drives the accumulation of alpha-synuclein protein, a key culprit in the development of Parkinson's disease.
https://medicalxpress.com/news/2024-04-simulations-reveal-mechanism-protein-buildup.html
Although Parkinson's disease has been recognized for more than 100 years, no treatments can slow or halt the disease's progress, let alone cure it. One of the major factors underlying this lack o...
https://medicalxpress.com/news/2024-04-links-cellular-parkinson.html
Scientists from the University of Aberdeen in collaboration with the University of Edinburgh and international partners, have identified a new way to detect signs of motor neuron disease (MND) in...
https://medicalxpress.com/news/2024-03-tool-motor-neuron-disease-symptoms.html
Imagine being middle aged and starting to feel that you are off balance a lot and that you are having a hard time coordinating your movements. Those are among the symptoms of Spinocerebellar atax...
https://medicalxpress.com/news/2024-03-discovery-rare-neurodegenerative-disease.html
Lewy body disease may be more common in middle-aged people than previously thought, according to a recent study by the University of Helsinki and the University of Tampere. In the study, almost 1...
https://medicalxpress.com/news/2024-03-common-degenerative-brain-disease-middle.html
The survival of neurons, unlike most other cells in the body, depends largely on the energy provided by mitochondria, intracellular organelles that contain their DNA to function properly.
https://medicalxpress.com/news/2024-03-mitochondrial-dna-fragment-losses-parkinson.html
Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome. The causes o...
https://medicalxpress.com/news/2024-03-accumulation-junk-proteins-aging-source.html
On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies...
https://medicalxpress.com/news/2024-03-movement-disorder-als-cognitive-ftld.html