Long-read sequencing data, particularly those derived from the Oxford Nanopore sequencing platform, tend to exhibit high error rates. Here, we present NextDenovo, an efficient error correction an...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03252-4
Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates. However, the la...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03257-z
Centrifuger is an efficient taxonomic classification method that compares sequencing reads against a microbial genome database. In Centrifuger, the Burrows-Wheeler transformed genome sequences ar...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03244-4
The proliferation antigen Ki-67 has been widely used in clinical settings for cancer staging for many years, but investigations on its biological functions have lagged. Recently, Ki-67 has been s...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03243-5
Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03223-9