The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.
By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.
Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage...
Investigators designed membrane permeant peptide inhibitors that specifically target the primary interface between TANGO1 and cTAGE5, an interaction that is required for collagen export from end...
Research indicated that TFDG administration effectively lowered the fasting blood glucose and serum lipid concentrations and enhanced the functionality and cellular architecture of the liver and...
The authors introduce the mechanisms and effects of native extracellular vesicles derived from different cells and tissues to treat liver diseases of different etiologies.
The authors explored the association of stemness indicators with survival outcomes and clinical characteristics by combining clinical information and survival analyses.
Researchers showed that hepatocyte-restricted expression of a single chain c-Jun~Fra-2 protein, which functionally mimiced the c-Jun/Fra-2 AP-1 dimer, resulted in spontaneous HCC formation in c-...
The US National Institutes of Health (NIH) said it will raise the salaries of thousands of postdoctoral researchers and graduate students who receive a prestigious NIH research fellowship. The m...
Scientists reported on Monday, April 22 that they used a form of the technology known as “base editing” to alter the DNA of laboratory monkeys in the womb, substantially reducing the levels ...
Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.