Patients in South Florida with metastatic melanoma will soon have access to tumor-infiltrating lymphocyte therapy, following its recent approval by the FDA. It will be available to patients at S...
The authors discuss how therapeutically targeting YAP through YAP inhibitors verteporfin and celastrol and its downstream mediators CCN1 and CCN2 might be useful in treating melanoma.
Scientists designed and evaluated targeted carbon nanotubes containing curcumin, and assessed their in vitro cytotoxicity effects on melanoma cancer cells.
The authors reported that galectin-3, mainly produced and secreted by macrophages, was elevated in islets from both high-fat diet-fed and diabetic mice.
The authors outline the processes of β-cell failure and detail the many β-cell abnormalities that manifest in people with diabetes mellitus.
Investigators described a normal breast explant model utilising a tuneable hydrogel which maintained epithelial proliferation, hormone receptor expression, and residency of T cells and macrophag...
The authors investigated the effects of miR-99a and miR-143 in single expression plasmids for breast cancer (BC) inhibition. Upregulation of miR-99a and miR-143 in any of the two selected BC cel...
Using preclinical models of spontaneous breast cancer metastasis, scientists investigated the impact of SMAD4 on the ability of bone morphogenetic protein 4 (BMP4) to regulate tumor growth and m...
Scientists identified a subset of myofibroblast cancer-associated fibroblast (CAFs) that were senescent (senCAF) in mouse and human breast tumors. SenCAFs were present in HER2+, ER+, and triple-...
The authors provide insights into the mechanism of exosome-derived non-coding RNAs (ncRNAs) in breast cancer (BC) drug resistance, thereby suggesting new strategies for the treatment of BC.
Two research projects on different aspects of breast cancer treatment led by Monash Biomedicine Discovery Institute researchers, Drs. Lan Nguyen and Thierry Jardé have been awarded a total of a...