by Irena Balzekas, Joshua Trzasko, Grace Yu, Thomas J. Richner, Filip Mivalt, Vladimir Sladky, Nicholas M. Gregg, Jamie Van Gompel, Kai Miller, Paul E. Croarkin, Vaclav Kremen, Gregory A. Worrell...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011152
by Kenneth Kay, Natalie Biderman, Ramin Khajeh, Manuel Beiran, Christopher J. Cueva, Daphna Shohamy, Greg Jensen, Xue-Xin Wei, Vincent P. Ferrera, LF Abbott Relational cognition—the ability to ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011954
by Bryce Morsky, Joshua B. Plotkin, Erol Akçay Reputations can foster cooperation by indirect reciprocity: if I am good to you then others will be good to me. But this mechanism for cooperation ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011979
by Florian E. C. Blanc, Anne Houdusse, Marco Cecchini Myosin motors use the energy of ATP to produce force and directed movement on actin by a swing of the lever arm. ATP is hydrolysed during the...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012005
by Marc D. Singleton, Michael B. Eisen Intrinsically disordered regions (IDRs) are segments of proteins without stable three-dimensional structures. As this flexibility allows them to interact wi...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012028
by Adam Husar, Mariam Ordyan, Guadalupe C. Garcia, Joel G. Yancey, Ali S. Saglam, James R. Faeder, Thomas M. Bartol, Mary B. Kennedy, Terrence J. Sejnowski Biochemical signaling pathways in livin...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011800
by Patrick Gemmell, Timothy B. Sackton, Scott V. Edwards, Jun S. Liu Genomes contain conserved non-coding sequences that perform important biological functions, such as gene regulation. We presen...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011995
by Jong Hyuk Byun, Hye Seon Jeon, Hwi-yeol Yun, Jae Kyoung Kim Target-mediated drug disposition (TMDD) is a phenomenon characterized by a drug’s high-affinity binding to a target molecule, whic...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012066
by Dong Ouyang, Yong Liang, Jinfeng Wang, Le Li, Ning Ai, Junning Feng, Shanghui Lu, Shuilin Liao, Xiaoying Liu, Shengli Xie Existing studies have shown that the abnormal expression of microRNAs ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011927
by Emma Beniston, Jordan P. Skittrall Influenza A virus contains regions of its segmented genome associated with ability to package the segments into virions, but many such regions are poorly cha...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012009
by Bingxian Xu, Dae-Sung Hwangbo, Sumit Saurabh, Clark Rosensweig, Ravi Allada, William L. Kath, Rosemary Braun The circadian clock is an evolutionarily-conserved molecular oscillator that enable...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012029
by Florian G. Pflug, Simon Haendeler, Christopher Esk, Dominik Lindenhofer, Jürgen A. Knoblich, Arndt von Haeseler Neural organoids model the development of the human brain and are an indispensa...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012054
by Alejandro Tlaie, Katharine Shapcott, Thijs L. van der Plas, James Rowland, Robert Lees, Joshua Keeling, Adam Packer, Paul Tiesinga, Marieke L. Schölvinck, Martha N. Havenith Trial-averaged me...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012000
by Shiro Kato, Yukiko Himeno, Akira Amano Since the left ventricle (LV) has pressure (Plv) and volume (Vlv), we can define LV elastance from the ratio between Plv and Vlv, termed as “instantane...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011974
by Kamil Wołos, Leszek Pstras, Malgorzata Debowska, Wojciech Dabrowski, Dorota Siwicka-Gieroba, Jan Poleszczuk Cardiovascular diseases are the leading cause of death globally, making the develop...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012013
by Anastasis Oulas, Kyriaki Savva, Nestoras Karathanasis, George M. Spyrou Prioritization or ranking of different cell types in a Single-cell RNA Sequencing (scRNA-Seq) framework can be performed...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011550
by Scott Boebinger, Aiden Payne, Giovanni Martino, Kennedy Kerr, Jasmine Mirdamadi, J. Lucas McKay, Michael Borich, Lena Ting The role of the cortex in shaping automatic whole-body motor behavior...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011562
by Danica Despotović, Corentin Joffrois, Olivier Marre, Matthew Chalk The efficient coding hypothesis posits that early sensory neurons transmit maximal information about sensory stimuli, given ...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011965
by Satyaki Roy, Shehzad Z. Sheikh, Terrence S. Furey Network inference is used to model transcriptional, signaling, and metabolic interactions among genes, proteins, and metabolites that identify...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012016
by Carolin Zitzmann, Ruian Ke, Ruy M. Ribeiro, Alan S. Perelson Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multi...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011437
by Arco Bast, Rieke Fruengel, Christiaan P. J. de Kock, Marcel Oberlaender Neurons in the cerebral cortex receive thousands of synaptic inputs per second from thousands of presynaptic neurons. Ho...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011468
by Yuhao Wang, Armin Lak, Sanjay G. Manohar, Rafal Bogacz When facing an unfamiliar environment, animals need to explore to gain new knowledge about which actions provide reward, but also put the...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011516
by Carla S. Griffiths, Jules M. Lebert, Joseph Sollini, Jennifer K. Bizley Animal psychophysics can generate rich behavioral datasets, often comprised of many 1000s of trials for an individual su...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011985
by Yiyang Shi, Mingxiu He, Junheng Chen, Fangfang Han, Yongming Cai Biomedical texts provide important data for investigating drug-drug interactions (DDIs) in the field of pharmacovigilance. Alth...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011989
by Jennifer A. Flegg, Sevvandi Kandanaarachchi, Philippe J. Guerin, Arjen M. Dondorp, Francois H. Nosten, Sabina Dahlström Otienoburu, Nick Golding Current malaria elimination targets must withs...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012017
by Adrian Lison, Sam Abbott, Jana Huisman, Tanja Stadler The time-varying effective reproduction number Rt is a widely used indicator of transmission dynamics during infectious disease outbreaks....
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012021
by Kevin Zhang, Junhao Zhu, Dehan Kong, Zhaolei Zhang Recent advances in single-cell sequencing technology have provided opportunities for mathematical modeling of dynamic developmental processes...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012015
by Luca Giudice, Ahmed Mohamed, Tarja Malm The Patient Similarity Network paradigm implies modeling the similarity between patients based on specific data. The similarity can summarize patients�...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012022
by KJE Hickman, Geoffrey Zahn Participating in mentored research is an enormous benefit to undergraduate students. These immersive experiences can dramatically improve retention and completion ra...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1011994
by Puranjan Ghimire, Mo Motamedi, Richard Joh Although the length and constituting sequences for pericentromeric repeats are highly variable across eukaryotes, the presence of multiple pericentro...
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012027