More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women.
https://medicalxpress.com/news/2024-07-brca12-men-screened-breast-cancer.html
A study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences reveals that the contribution of cells expressing maternal or paternal X chromosom...
https://medicalxpress.com/news/2024-07-maternal-paternal-chromosomes-skewed-tissues.html
University of Toronto researchers have identified two genes that play a critical role in tumor growth in the pancreas—findings that have significant implications for understanding and treating ...
https://medicalxpress.com/news/2024-07-critical-genes-pancreatic-tumors.html
When we form a new memory, the brain undergoes physical and functional changes known collectively as a "memory trace." A memory trace represents the specific patterns of activity and structural m...
https://medicalxpress.com/news/2024-07-epigenetics-memory-formation.html
Researchers from North Carolina State University have developed an array that assesses methylation levels of genes located in imprint control regions (ICRs) within the human genome. The array rep...
https://medicalxpress.com/news/2024-07-array-imprinted-genes-potential-links.html
Millions of adults have atrial fibrillation—an irregular beating of the upper chambers of the heart that yields increased risk of heart failure, stroke and death. Many genetic mutations in the ...
https://medicalxpress.com/news/2024-07-tiny-deletion-heart-muscle-protein.html
Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to ...
https://medicalxpress.com/news/2024-07-gene-therapy-approach-duchenne-muscular.html
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania revealed the most extensive single cell atlas of the human kidney, ...
https://medicalxpress.com/news/2024-07-cell-kidney-atlas-potential-treatments.html
Scientists have uncovered that "gene misbehavior"—where genes are active when they were expected to be switched off—is a surprisingly common phenomenon in the healthy human population.
https://medicalxpress.com/news/2024-07-scientists-gene-misbehavior-widespread-healthy.html
Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the Univers...
https://medicalxpress.com/news/2024-07-genetic-mutations-tlr7-genes-severe.html
Researchers at Simon Fraser University, in collaboration with a group from Baylor College of Medicine in Texas, have identified a gene that appears to reverse Parkinson's disease symptoms in frui...
https://medicalxpress.com/news/2024-07-fruit-fly-gene-reverse-parkinson.html
A new and freely available Human Gut Microbiome Atlas could help researchers and health care professionals around the world better understand how microorganisms in the gut impact disease, leading...
https://medicalxpress.com/news/2024-07-gut-microbiome-atlas-accurate-profile.html
As part of a breast cancer diagnosis, pathologists take cells from a biopsy and check them under a microscope. Most cancerous cells form roundish clumps, known as no special type, or invasive duc...
https://medicalxpress.com/news/2024-07-tumors-collide-analysis-breast-cancer.html
A new study by scientists at deCODE Genetics shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases and o...
https://medicalxpress.com/news/2024-07-links-sequence-variants-dna-methylation.html
A team of researchers at NYU Abu Dhabi, led by Professor Sehamuddin Galadari, has discovered that the tumor suppressor protein Prostate apoptosis response-4 (Par-4) can cause a unique type of cel...
https://medicalxpress.com/news/2024-07-tumor-suppressor-protein-par-trigger.html
Researchers at the Leibniz Institute for Immunotherapy (LIT) describe a new type of regulation of immune cells by so-called "jumping genes."
https://medicalxpress.com/news/2024-07-epigenetics-genes-immune-cells-tissue.html
The protein tau is essential to the function of cells in the brain and central nervous system, but when over-produced under certain conditions, it forms tangles that clog the cells' internal stru...
https://medicalxpress.com/news/2024-07-gene-therapy-discovery-triggers-glaucoma.html
Cancer is caused by genetic changes that occur in our cells over time. There are two main types of changes, namely somatic mutations, which are alterations in the DNA sequence, and copy number al...
https://medicalxpress.com/news/2024-07-patterns-cancer-genetics-tumor-suppressor.html
Despite rapid advances in genetic testing in recent decades, more than half of people worldwide with suspected Mendelian genetic disorders do not have an accurate molecular diagnosis. Others endu...
https://medicalxpress.com/news/2024-07-sequencing-technique-complex-genomic-variants.html
A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study l...
https://medicalxpress.com/news/2024-07-preclinical-insights-parkinson-disease.html
Parkinson's disease is the world's fastest growing neurological condition. Currently there are no drugs or therapies that slow or stop the progression of the disease.
https://medicalxpress.com/news/2024-07-protein-discovery-linked-parkinson-disease.html
People who experience an arterial ischemic stroke (AIS) or transient ischemic stroke (TIA) are at an increased risk of suffering a second stroke or other major adverse cardiovascular event (MACE)...
https://medicalxpress.com/news/2024-07-proteins-contribute-recurrence.html
Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine of the University of Pennsylvania (Penn Medicine) developed data designed to improve the diagnosis ...
https://medicalxpress.com/news/2024-07-high-throughput-variant-reclassification-aids.html
The majority of rare diseases have a genetic cause. The underlying genetic alteration can be found more and more easily, for example, by means of exome sequencing (ES), leading to a molecular gen...
https://medicalxpress.com/news/2024-07-genetic-diagnostics-ultra-rare-diseases.html
Northwestern Medicine scientists have uncovered molecular mechanisms underlying lymphatic valve development, a discovery which could prove useful in treating lymphedema, according to a study publ...
https://medicalxpress.com/news/2024-07-molecular-drivers-lymphedema.html
Researchers in the lab of Jean Cook, Ph.D., chair and professor in the Department of Biochemistry and Biophysics, have identified the cellular processes that occur when you take a cancer drug mea...
https://medicalxpress.com/news/2024-07-cancer-cells-treatment.html
The majority of genetic studies focus on people of European descent, which limits the understanding of how genes influence health in other populations. Now researchers at the Perelman School of M...
https://medicalxpress.com/news/2024-07-genetic-highlights-importance-diversity-health.html
Disorders/differences of sex development (DSD) are difficult to diagnose because of the multiple phenotypes and genes involved, but a new technique developed at Hudson Institute of Medical Resear...
https://medicalxpress.com/news/2024-07-technique-disorders-sex.html
In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University of Manitoba and collaborating institutions have revealed an unex...
https://medicalxpress.com/news/2024-07-reveal-unexpected-role-protein-otx2.html
A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become...
https://medicalxpress.com/news/2024-07-distinct-pathway-key-driver-epithelial.html