Investigators explored the possibilities of ependymal repair in GMH/PHH using a combination of neural stem cells, ependymal progenitors, and mesenchymal stem cells.
Using a cell enrichment strategy to isolate KIT+/CD45− cells from the telogen skin of adult female C57BL/6J mice, investigators evaluated the transcriptional landscape of quiescent melanocyte ...
A serum-derived phospholipid, lysophosphatidic acid (LPA), was identified as an important biologic inhibitor of RIPK4. LPA functioned by inhibiting the transcription of RIPK4 mRNA.
Scientists investigated how ECM composition modulated CD8+ T cell function in undifferentiated pleomorphic sarcoma, an immunologically active desmoplastic tumor.
Bottlebrush polymers were synthesized and crosslinked to form poly(ethylene glycol)-based hydrogels and used to study how strain-stiffening behavior affects human MSCs.
Scientists investigated the anti-acute myelogenous leukemia (AML) activity of bortezomib, emphasizing its anti-leukemic stem cells potential, using KG-1a cells, an AML cell line with stem-like p...
The authors performed ex vivo drug screening of CML CD34+ leukemic stem/progenitor cells using 100 single drugs and tyrosine kinase inhibitor-drug combinations and identify sensitivities to Wee1...
Delilah Hendriks, researcher from the Organoid group, Oncode researcher, and affiliated group leader at the Princess Máxima Center has received a Young Investigator Grant from the Dutch Cancer ...
Scientists tested whether hypertensive pregnancy involved localized aberrations in uterine arterial tone, stiffness and remodeling by matrix metalloproteinases.
The authors showed that Tn64 bound to Tn fn repeats 3–5. Unlike other Tn fn domains, Tn fn 3–5 displayed no inhibition of fibronectin matrix assembly.
Scientists examined how proteolysis-related biomarkers and ECM remodeling factors respond to a bout of resistance training in the untrained and trained state.