Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistant Klebsiella pneumoniae as a priority pathogen for wh...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01342-3
Using computational tools, bulk transcriptomics can be deconvoluted to estimate the abundance of constituent cell types. However, existing deconvolution methods are conditioned on the assumption ...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01338-z
The clinical utility of genetic information for type 2 diabetes (T2D) prediction with polygenic scores (PGS) in ancestrally diverse, real-world US healthcare systems is unclear, especially for th...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01337-0
Genetic variants that severely alter protein products (e.g. nonsense, frameshift) are often associated with disease. For some genes, these predicted loss-of-function variants (pLoFs) are observed...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01333-4
The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propos...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01329-0