Omics! Omics!

What is now way back in February, Alexander Hoischen presented a talk at AGBT which described early results from an effort to apply PacBio HiFi sequencing at scale for solving rare disease cases....

http://omicsomics.blogspot.com/2024/05/hifi-wgs-as-nearly-unified-tool-for.html

Technologies vying for state-of-the-art in human genome analysis are a recurrent theme in this space, and there are many ideas on this in the collection I really need to get out over the next two...

http://omicsomics.blogspot.com/2024/05/dovetail-transposes-their-hi-c.html

An exciting aspect of true single molecule sequencing has been the detection of methylated bases.  Both Oxford Nanopore and Pacific Biosciences technology generate altered signals if methylated ...

http://omicsomics.blogspot.com/2024/05/on-expanding-versatility-of-single.html

Readers of this space might have detected a significant slant towards skepticism in my coverage of Illumina Complete Long Reads (iCLR), exacerbated by now deposed Illumina CEO Francis deSouza cla...

http://omicsomics.blogspot.com/2024/05/first-illumina-complete-long-reads.html

A number of academic labs and startups have been trying to build new ways of parallel sequencing of large numbers of peptides using schemes that have significant resemblance in their logic to the...

http://omicsomics.blogspot.com/2024/04/a-peek-at-quantumsis-protein-sequencer.html

NanoString declaring bankruptcy on the eve of 2024's edition of AGBT was a shock to many at the meeting and then there was confusion: would one of the sponsors have a dark booth? The aggressive 1...

http://omicsomics.blogspot.com/2024/04/bruker-wins-nanostring-auction.html

PacBio announced preliminary earnings yesterday, and the nearly immediate result was a 50% plunge in their share price.  Along with the earnings, the company announced significant cost cutting....

http://omicsomics.blogspot.com/2024/04/pacbio-plummets.html

A new preprint based on Genomics UK data has identified a set of single base insertion mutations (predominantly a specific A insertion)  in a spliceosomal RNA which is responsible for about 0....

http://omicsomics.blogspot.com/2024/04/thoughts-on-rnu4-2-mutation-paper.html

It's been just a few weeks since I sat poolside at AGBT with VizGen CEO Terry Lo and Scale Biosciences CEO Giovanna Prout to discuss the two companies' new partnership.  Well, that would have be...

http://omicsomics.blogspot.com/2024/03/post-agbt-vizgen-scale-biosciences.html

While I still have a pair of pre-AGBT and AGBT interviews to write up - plus a long list of post ideas inspired by AGBT - breaking news about BioNano Genomics takes precedence.  The company has ...

http://omicsomics.blogspot.com/2024/03/bionanos-in-peril-again.html

Some updates on the sequencing instrument vendors, save Ultima Genomics and Element Biosciences which I've covered already. Read more »

http://omicsomics.blogspot.com/2024/02/post-agbt-sequencing-hardware-roundup.html

Element has been very busy over the past year and in the Silver Sponsor presentation covered updates since last AGBT as well as a number of completely new items.  I covered their Teton approach ...

http://omicsomics.blogspot.com/2024/02/post-agbt-element-aviti-sequencing.html

Element Biosciences and Singular Genomics have often appeared to be on roughly parallel trajectories, though with key differences.  Both companies launched sequencing instruments with NextSeq 20...

http://omicsomics.blogspot.com/2024/02/post-agbt-both-element-singular-want.html

A confusion of ideas for AGBT follow-up have collided with the inevitable post-AGBT return-to-ordinary-life requirements.  To try to avoid a huge project that never gets completed, I'm breaking ...

http://omicsomics.blogspot.com/2024/02/agbt-follow-up-ultima-genomics-ug100.html

Here at AGBT, VoltaLabs has unveiled their 24-sample DNA extraction and NGS library prep Callisto instrument, which is particularly suited for long read applications but is also suited for short...

http://omicsomics.blogspot.com/2024/02/voltalabs-launches-callisto-for-dna.html

Has there ever been a product you’ve just wanted to have, but it doesn’t exist? That keeps popping up in discussions - “if only we had X this project would go so much faster!”. Well, N6 T...

http://omicsomics.blogspot.com/2024/02/iconpcr-super-flexible-qpcr.html

Just as the AGBT hype cycle was firing up (with me contributing multiple sparks), serial entrepreneur Jonathan Rothberg's latest sequencing startup 454.bio fully de-stealthed their technology thi...

http://omicsomics.blogspot.com/2024/02/want-to-build-sequencer-454bio-opens-up.html

As part of the run-up to Gold sponsorship at AGBT, Ultima Genomics held a multi-day event in early December, with tours of the headquarters facility and factory floor in the Bay Area and a day at...

http://omicsomics.blogspot.com/2024/02/ultima-launches.html

Studying how Illumina came to dominate sequencing markets is certainly worthy of at least a Harvard Business School case study, and perhaps an entire graduate thesis.  But I wanted to give a qui...

http://omicsomics.blogspot.com/2024/01/on-illuminas-moats-past-present.html

It's January, and that means the J.P. Morgan Healthcare Conference looms next week -- followed by AGBT just a month later.  Indeed, I've been trying to mark out the "can't miss" talks for AGBT s...

http://omicsomics.blogspot.com/2024/01/2024-look-ahead.html

In a piece on LinkedIn, Brian Krueger made a pithy comment that should give PacBio management pause.  In a series of bulletpoints he summarized key things he had heard from ASHG, and the one fo...

http://omicsomics.blogspot.com/2023/11/should-pacbio-abandon-their-set-list.html

Oxford Nanopore's adaptive sequencing scheme is truly singular (but not Singular!), enabling computational adjustment of the sequencing process as it occurs.  A number of academics have demonstr...

http://omicsomics.blogspot.com/2023/10/concept-oxford-nanopore-adaptive.html

PacBio CEO Christian Henry chatted with me recently by teleconference on a variety of topics, but the focus was the recent PacBio acquisition of Apton Biosystems for $85M in equity.  As a regul...

http://omicsomics.blogspot.com/2023/09/chatting-apton-acquisition-with-pacbio.html

A significant challenge for the long read sequencing vendors has been that short read sequencing has a decade and a half head start in evolving a tools ecosystem.  New entrants such as Singular ...

http://omicsomics.blogspot.com/2023/09/two-more-automation-partners-join.html

Wednesday night brought the news that Pacific Biosciences has both officially launched their Onso desktop short read sequencer and bought technology for a high throughput version of it by acquiri...

http://omicsomics.blogspot.com/2023/08/apton-super-resolution-to-be-acquired.html