Vision depends on the interplay between photoreceptor cells of the neural retina and the underlying retinal pigment epithelium (RPE). Most genes involved in inherited retinal diseases display spe...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03250-6
Single-cell CRISPR screens (perturb-seq) link genetic perturbations to phenotypic changes in individual cells. The most fundamental task in perturb-seq analysis is to test for association between...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03254-2
Numerous algorithms have been proposed to identify cell types in single-cell RNA sequencing data, yet a fundamental problem remains: determining associations between cells and phenotypes such as ...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03263-1
Genomic regions that remain poorly understood, often referred to as the dark genome, contain a variety of functionally relevant and biologically informative features. These include endogenous vir...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03258-y
Pluripotent states of embryonic stem cells (ESCs) with distinct transcriptional profiles affect ESC differentiative capacity and therapeutic potential. Although single-cell RNA sequencing has rev...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03268-w