Genome Biology - Latest Comments

Spatial molecular data has transformed the study of disease microenvironments, though, larger datasets pose an analytics challenge prompting the direct adoption of single-cell RNA-sequencing tool...

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03241-7

Amino acid substitutions can perturb protein activity in multiple ways. Understanding their mechanistic basis may pinpoint how residues contribute to protein function. Here, we characterize the m...

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03238-2

Aneuploidy, an abnormal number of chromosomes within a cell, is a hallmark of cancer. Patterns of aneuploidy differ across cancers, yet are similar in cancers affecting closely related tissues. T...

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03225-7

We present a non-parametric statistical method called TDEseq that takes full advantage of smoothing splines basis functions to account for the dependence of multiple time points in scRNA-seq stud...

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03237-3

As most viruses remain uncultivated, metagenomics is currently the main method for virus discovery. Detecting viruses in metagenomic data is not trivial. In the past few years, many bioinformatic...

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03236-4