Inflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to share common pathophysiological processes. LRRK2 has been implicated as playing a...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01335-2
The most accessed research articles published by Genome Medicine
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01343-2
Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistant Klebsiella pneumoniae as a priority pathogen for wh...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01342-3
Using computational tools, bulk transcriptomics can be deconvoluted to estimate the abundance of constituent cell types. However, existing deconvolution methods are conditioned on the assumption ...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01338-z
Genetic variants that severely alter protein products (e.g. nonsense, frameshift) are often associated with disease. For some genes, these predicted loss-of-function variants (pLoFs) are observed...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-024-01333-4