by George J. Watase, Yukiko M. Yamashita Ribosomal DNA (rDNA), which encodes ribosomal RNA, is an essential but unstable genomic element due to its tandemly repeated nature. rDNA’s repetitive n...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011136
by Frederik J. H. de Haas, Léna Kläy, Florence Débarre, Sarah P. Otto Engineered gene-drive techniques for population modification and/or suppression have the potential for tackling complex ch...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011262
by Nicolas L. Fernandez, Lyle A. Simmons Regulation of transcription is a fundamental process that allows bacteria to respond to external stimuli with appropriate timing and magnitude of response...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011283
by Christopher T. Pappas, Rachel M. Mayfield, Ava E. Dickerson, Lei Mi-Mi, Carol C. Gregorio The leiomodin (Lmod) family of actin-binding proteins play a critical role in muscle function, highlig...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011279
by Mahima Sagar Sahu, Rajaram Purushotham, Rupinder Kaur CgHog1, terminal kinase of the high-osmolarity glycerol signalling pathway, orchestrates cellular response to multiple external stimuli in...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011281
by Brandon M. Waddell, Cheng-Wei Wu The Integrator is a multi-subunit protein complex that catalyzes the maturation of snRNA transcripts via 3’ cleavage, a step required for snRNA incorporation...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011284
by Xuewei Cao, Shuanglin Zhang, Qiuying Sha Joint analysis of multiple correlated phenotypes for genome-wide association studies (GWAS) can identify and interpret pleiotropic loci which are essen...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011245
by Ziqian Xie, Tao Zhang, Sangbae Kim, Jiaxiong Lu, Wanheng Zhang, Cheng-Hui Lin, Man-Ru Wu, Alexander Davis, Roomasa Channa, Luca Giancardo, Han Chen, Sui Wang, Rui Chen, Degui Zhi Existing imag...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011273
by Megan R. Majocha, Devin E. Jackson, Ngoc-Han Ha, Ruhul Amin, Marie Pangrácová, Christina R. Ross, Howard H. Yang, Maxwell P. Lee, Kent W. Hunter Patients with ER-negative breast cancer have ...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011236
by Sravanthi S. P. Nadiminti, Shirley B. Dixit, Neena Ratnakaran, Anushka Deb, Sneha Hegde, Sri Padma Priya Boyanapalli, Sierra Swords, Barth D. Grant, Sandhya P. Koushika Synaptic vesicle protei...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011253
by Nihar Bhattacharyya, Niuzheng Chai, Nathaniel J. Hafford-Tear, Amanda N. Sadan, Anita Szabo, Christina Zarouchlioti, Jana Jedlickova, Szi Kay Leung, Tianyi Liao, Lubica Dudakova, Pavlina Skali...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011230
by The PLOS Genetics Editors
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011269
by The PLOS Genetics Editors
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011270
by Lev M. Z. Tsypin, Scott H. Saunders, Allen W. Chen, Dianne K. Newman The capacity for bacterial extracellular electron transfer via secreted metabolites is widespread in natural, clinical, and...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011064
by Xueyao Wu, Changfeng Xiao, Danielle Rasooly, Xunying Zhao, Cynthia Casson Morton, Xia Jiang, C. Scott Gallagher Age at first sexual intercourse (AFS) and lifetime number of sexual partners (NS...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011268
by Tomáš Najer, Jorge Doña, Aleš Buček, Andrew D. Sweet, Oldřich Sychra, Kevin P. Johnson While mitochondrial genome content and organization is quite diverse across all Eukaryotes, most bi...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011266
by Aravindh Nagarajan, Kristin Scoggin, Jyotsana Gupta, Manuchehr Aminian, L. Garry Adams, Michael Kirby, David Threadgill, Helene Andrews-Polymenis Staphylococcus aureus (S. aureus) is an opport...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011229
by Isabella Schember, William Reid, Geyenna Sterling-Lentsch, Marc S. Halfon Transcriptional cis-regulatory modules, e.g., enhancers, control the time and location of metazoan gene expression. Wh...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010891
by Matthew P. Moore, Mirjam Laager, Paolo Ribeca, Xavier Didelot By decomposing genome sequences into k-mers, it is possible to estimate genome differences without alignment. Techniques such as k...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011184
by Elizabeth L. Graham, Joel Fernandez, Shagun Gandhi, Iqra Choudhry, Natalia Kellam, Jeannine R. LaRocque Accurate repair of DNA double-strand breaks (DSBs) is essential for the maintenance of g...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011250
by Francois D. Rouleau, Alexandre K. Dubé, Isabelle Gagnon-Arsenault, Soham Dibyachintan, Alicia Pageau, Philippe C. Després, Patrick Lagüe, Christian R. Landry Pneumocystis jirovecii is a fun...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011252
by Alexandra R. Schmidt, Haiden J. Placer, Ishmael M. Muhammad, Rebekah Shephard, Regina L. Patrick, Taylor Saurborn, Eric J. Horstick, Sadie A. Bergeron As essential components of gene expressio...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011139
by Michael J. Turingan, Tan Li, Jenna Wright, Abhishek Sharma, Kate Ding, Shahoon Khan, Byoungchun Lee, Savraj S. Grewal Animals often grow and develop in unpredictable environments where factors...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011232
by Sophia Gunn, Kathryn L. Lunetta Polygenic scores (PGS) are measures of genetic risk, derived from the results of genome wide association studies (GWAS). Previous work has proposed the coeffici...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011249
by Darius Camp, Bhavya Venkatesh, Veronika Solianova, Lorena Varela, Benjamin T. Goult, Guy Tanentzapf Cell adhesion requires linkage of transmembrane receptors to the cytoskeleton through interm...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011224
by Kory P. Luedke, Jiro Yoshino, Chang Yin, Nan Jiang, Jessica M. Huang, Kevin Huynh, Jay Z. Parrish An animal’s skin provides a first point of contact with the sensory environment, including n...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011237
by Callan O’Connor, Gregory R. Keele, Whitney Martin, Timothy Stodola, Daniel Gatti, Brian R. Hoffman, Ron Korstanje, Gary A. Churchill, Laura G. Reinholdt The health risks that arise from envi...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011248
by Boxi Lin, Andrew D. Paterson, Lei Sun Genetic effects can be sex-specific, particularly for traits such as testosterone, a sex hormone. While sex-stratified analysis provides easily interpreta...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011221
by Liu Xu, Yibing Chen, Lingling Liu, Xinyu Hu, Chengsi He, Yuan Zhou, Xinyi Ding, Minhua Luo, Jiajing Yan, Quentin Liu, Hongsheng Li, Dongming Lai, Zhengzhi Zou Tumor-associated macrophages (TAM...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011235
by Peiyao Wang, Zhaotong Lin, Haoran Xue, Wei Pan Genome-wide association studies (GWAS) have identified many genetic loci associated with complex traits and diseases in the past 20 years. Multip...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011246