Small RNAs are essential for germ cell development and fertilization. However, fundamental questions remain, such as the level of conservation in small RNA composition between species and whether...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03214-w
The problem of missing heritability requires the consideration of genetic interactions among different loci, called epistasis. Current GWAS statistical models require years to assess the entire c...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03202-0
Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential but require optimiz...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03215-9
B-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organizatio...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-024-03212-y
We develop a large-scale single-cell ATAC-seq method by combining Tn5-based pre-indexing with 10× Genomics barcoding, enabling the indexing of up to 200,000 nuclei across multiple samples in a...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03150-1